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| matrix metalloproteinase inhibitor ： ウィキペディア英語版 |
matrix metalloproteinase inhibitor
A matrix metalloproteinase inhibitor (MMPI) inhibits matrix metalloproteinases. As they inhibit cell migration they have antiangiogenic effects. They may be both endogenous and exogenous.
The most notorious ''endogenous'' metalloproteinases are tissue inhibitors of metalloproteinases (TIMPs). There are also cartilage-derived angiogenesis inhibitors.
''Exogenous'' matrix metalloproteinase inhibitors that were developed as anticancer drugs include batimastat and marimastat.
Metalloproteinase inhibitors are found in numerous marine organisms, including fish, cephalopods, mollusks, algea and bacteria.
==See also==
* Drug discovery and development of MMP inhibitors
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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